Structural basis for the autoinhibition of talin in regulating integrin activation

Activation of heterodimeric (α/β) integrin transmembrane receptors by the 270 kDa cytoskeletal protein talin is essential for many important cell adhesive and physiological responses. A key step in this process involves interaction of phosphotyrosine-binding (PTB) domain in the N-terminal head of ta...

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Bibliografiske detaljer
Main Authors: Goksoy, Esen, Ma, Yan-Qing, Wang, Xiaoxia, Kong, Xiangming, Perera, Dhanuja, Plow, Edward F., Qin, Jun
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2522368/
https://ncbi.nlm.nih.gov/pubmed/18614051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.06.011
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