Effect of Structural and Stereochemical Methylproline Isomers on Actinomycin Biosynthesis

The inhibitory effect of methylprolines on actinomycin biosynthesis by Streptomyces antibioticus was studied; the order of effectiveness was 3- >4- >5-methyl-dl-proline. Cis-3-methyl-dl-proline was 14 times more active than the trans isomer. It was also found that 4- and, possibly, 5-methylproline w...

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Pubblicato in:	J Bacteriol
Autori principali:	Yoshida, Tadashi, Mauger, Anthony, Weissbach, Herbert, Katz, Edward
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1968
Soggetti:	Microbial Physiology and Metabolism
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC252115/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4171116/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.95.3.952-958.1968
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