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Effect of Structural and Stereochemical Methylproline Isomers on Actinomycin Biosynthesis

The inhibitory effect of methylprolines on actinomycin biosynthesis by Streptomyces antibioticus was studied; the order of effectiveness was 3- >4- >5-methyl-dl-proline. Cis-3-methyl-dl-proline was 14 times more active than the trans isomer. It was also found that 4- and, possibly, 5-methylproline w...

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Publicat a:J Bacteriol
Autors principals: Yoshida, Tadashi, Mauger, Anthony, Weissbach, Herbert, Katz, Edward
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 1968
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC252115/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4171116/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.95.3.952-958.1968
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