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Dissecting the mechanism of Epac activation by hydrogen/deuterium exchange FT-IR and structural modeling
Exchange proteins directly activated by cAMP (Epac) is a family of cAMP-binding domain containing proteins that play important roles in mediating the effects of cAMP through the activation of down-stream small GTPases, Ras-proximate proteins. To delineate the mechanism of Epac activation, we probed...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519952/ https://ncbi.nlm.nih.gov/pubmed/17176054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi061701x |
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