Interferon Regulatory Factor IRF-7 Induces the Antiviral Alpha Interferon Response and Protects against Lethal West Nile Virus Infection

Type I interferon (IFN-α/β) comprises a family of immunomodulatory cytokines that are critical for controlling viral infections. In cell culture, many RNA viruses trigger IFN responses through the binding of RNA recognition molecules (RIG-I, MDA5, and TLR-3) and induction of interferon regulatory fa...

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Bibliografiska uppgifter
Huvudupphovsmän: Daffis, Stephane, Samuel, Melanie A., Suthar, Mehul S., Keller, Brian C., Gale, Michael, Diamond, Michael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Pathogenesis and Immunity
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519659/
https://ncbi.nlm.nih.gov/pubmed/18562536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00918-08
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