Differential Requirements of the C Terminus of Nbs1 in Suppressing Adenovirus DNA Replication and Promoting Concatemer Formation

Adenoviruses (Ad) with the early region E4 deleted (E4-deleted virus) are defective for DNA replication and late protein synthesis. Infection with E4-deleted viruses results in activation of a DNA damage response, accumulation of cellular repair factors in foci at viral replication centers, and join...

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Autori principali: Lakdawala, Seema S., Schwartz, Rachel A., Ferenchak, Kevin, Carson, Christian T., McSharry, Brian P., Wilkinson, Gavin W., Weitzman, Matthew D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Virus-Cell Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519655/
https://ncbi.nlm.nih.gov/pubmed/18562516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00900-08
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