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Function of Heterologous Mycobacterium tuberculosis InhA, a Type 2 Fatty Acid Synthase Enzyme Involved in Extending C(20) Fatty Acids to C(60)-to-C(90) Mycolic Acids, during De Novo Lipoic Acid Synthesis in Saccharomyces cerevisiae

We describe the physiological function of heterologously expressed Mycobacterium tuberculosis InhA during de novo lipoic acid synthesis in yeast (Saccharomyces cerevisiae) mitochondria. InhA, representing 2-trans-enoyl-acyl carrier protein reductase and the target for the front-line antituberculous...

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Bibliografski detalji
Glavni autori: Gurvitz, Aner, Hiltunen, J. Kalervo, Kastaniotis, Alexander J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519256/
https://ncbi.nlm.nih.gov/pubmed/18552191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00655-08
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