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Function of Heterologous Mycobacterium tuberculosis InhA, a Type 2 Fatty Acid Synthase Enzyme Involved in Extending C(20) Fatty Acids to C(60)-to-C(90) Mycolic Acids, during De Novo Lipoic Acid Synthesis in Saccharomyces cerevisiae

We describe the physiological function of heterologously expressed Mycobacterium tuberculosis InhA during de novo lipoic acid synthesis in yeast (Saccharomyces cerevisiae) mitochondria. InhA, representing 2-trans-enoyl-acyl carrier protein reductase and the target for the front-line antituberculous...

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Библиографические подробности
Главные авторы: Gurvitz, Aner, Hiltunen, J. Kalervo, Kastaniotis, Alexander J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology (ASM) 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519256/
https://ncbi.nlm.nih.gov/pubmed/18552191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.00655-08
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