Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis

Hemoglobin (Hb) potently inactivates the nitric oxide (NO) radical via a dioxygenation reaction forming nitrate (NO(3)(−)). This inactivation produces endothelial dysfunction during hemolytic conditions and may contribute to the vascular complications of Hb-based blood substitutes. Hb also functions...

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Bibliographic Details
Main Authors:	Minneci, Peter C., Deans, Katherine J., Shiva, Sruti, Zhi, Huang, Banks, Steven M., Kern, Steven, Natanson, Charles, Solomon, Steven B., Gladwin, Mark T.
Format:	Artigo
Language:	Inglês
Published:	American Physiological Society 2008
Subjects:	Articles
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2519206/ https://ncbi.nlm.nih.gov/pubmed/18552166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00151.2008
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Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis

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