Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin

During intravascular hemolysis in human disease, vasomotor tone and organ perfusion may be impaired by the increased reactivity of cell-free plasma hemoglobin (Hb) with NO. We experimentally produced acute intravascular hemolysis in a canine model in order to test the hypothesis that low levels of d...

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Detalhes bibliográficos
Main Authors: Minneci, Peter C., Deans, Katherine J., Zhi, Huang, Yuen, Peter S.T., Star, Robert A., Banks, Steven M., Schechter, Alan N., Natanson, Charles, Gladwin, Mark T., Solomon, Steven B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283939/
https://ncbi.nlm.nih.gov/pubmed/16294219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25040
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