In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines

BACKGROUND: Cell-free hemoglobin (Hb) in the vasculature leads to vasoconstriction and injury. Proposed mechanisms have been based on nitric oxide (NO) scavenging by oxyhemoglobin (oxyHb) or processes mediated by oxidative reactions of methemoglobin (metHb). To clarify this, we tested the vascular e...

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Detalhes bibliográficos
Main Authors: Wang, Dong, Piknova, Barbora, Solomon, Steven B., Cortes-Puch, Irene, Kern, Steven J., Sun, Junfeng, Kanias, Tamir, Gladwin, Mark T., Helms, Christine, Kim-Shapiro, Daniel B., Schechter, Alan. N, Natanson, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3686899/
https://ncbi.nlm.nih.gov/pubmed/23488474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/trf.12162
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