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Sir2 Protein Deacetylases: Evidence for Chemical Intermediates and Functions of a Conserved Histidine
Sir2 NAD(+)-dependent protein deacetylases are implicated in a variety of cellular processes such as apoptosis, gene silencing, life-span regulation, and fatty acid metabolism. In spite of this, there have been relatively few investigations into the detailed chemical mechanism. Sir2 proteins (sirtui...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519119/ https://ncbi.nlm.nih.gov/pubmed/16388603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi052014t |
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