A phylogenetically conserved NAD(+)-dependent protein deacetylase activity in the Sir2 protein family

The yeast Sir2 protein, required for transcriptional silencing, has an NAD(+)-dependent histone deacetylase (HDA) activity. Yeast extracts contain a NAD(+)-dependent HDA activity that is eliminated in a yeast strain from which SIR2 and its four homologs have been deleted. This HDA activity is also d...

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Bibliografiske detaljer
Main Authors: Smith, Jeffrey S., Brachmann, Carrie Baker, Celic, Ivana, Kenna, Margaret A., Muhammad, Shabazz, Starai, Vincent J., Avalos, Jose L., Escalante-Semerena, Jorge C., Grubmeyer, Charles, Wolberger, Cynthia, Boeke, Jef D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC18692/
https://ncbi.nlm.nih.gov/pubmed/10841563
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