A phylogenetically conserved NAD(+)-dependent protein deacetylase activity in the Sir2 protein family

The yeast Sir2 protein, required for transcriptional silencing, has an NAD(+)-dependent histone deacetylase (HDA) activity. Yeast extracts contain a NAD(+)-dependent HDA activity that is eliminated in a yeast strain from which SIR2 and its four homologs have been deleted. This HDA activity is also d...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Smith, Jeffrey S., Brachmann, Carrie Baker, Celic, Ivana, Kenna, Margaret A., Muhammad, Shabazz, Starai, Vincent J., Avalos, Jose L., Escalante-Semerena, Jorge C., Grubmeyer, Charles, Wolberger, Cynthia, Boeke, Jef D.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2000
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18692/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10841563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.12.6658
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