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Sir2 Deacetylases Exhibit Nucleophilic Participation of Acetyl-lysine in NAD(+) Cleavage
[Image: see text] Sir2 deacetylases (sirtuins) couple the deacetylation of lysine residues with conversion of NAD+ to O-acetyl-ADP-ribose (OAADPr) and nicotinamide. Sirtuins are potential targets for the treatment of diabetes, ageing, cancer, and neurodegenerative diseases. The most debated portion...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2568996/ https://ncbi.nlm.nih.gov/pubmed/17439123 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja070162w |
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