Paclitaxel loading in PLGA nanospheres affected the in vitro drug cell accumulation and antiproliferative activity

BACKGROUND: PTX is one of the most widely used drug in oncology due to its high efficacy against solid tumors and several hematological cancers. PTX is administered in a formulation containing 1:1 Cremophor(® )EL (polyethoxylated castor oil) and ethanol, often responsible for toxic effects. Its enca...

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Autori principali: Vicari, Luisa, Musumeci, Teresa, Giannone, Ignazio, Adamo, Luana, Conticello, Concetta, De Maria, Ruggero, Pignatello, Rosario, Puglisi, Giovanni, Gulisano, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2008
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519087/
https://ncbi.nlm.nih.gov/pubmed/18657273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-212
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