Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells

BACKGROUND: To specifically deliver paclitaxel (PTX) to retinoblastoma (RB) cells, the anionic surface-charged poly(lactic-co-glycolic acid) (PLGA) NPs loaded with paclitaxel were conjugated with epithelial cell adhesion molecule (EpCAM) antibody for enhancing site-specific intracellular delivery of...

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Bibliographic Details
Main Authors: Mitra, Moutushy, Misra, Ranjita, Harilal, Anju, Sahoo, Sanjeeb K, Krishnakumar, Subramanian
Format: Artigo
Language:Inglês
Published: Molecular Vision 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209422/
https://ncbi.nlm.nih.gov/pubmed/22065926
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