Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

Iron is essential for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated. Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythrocyt...

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Bibliografski detalji
Glavni autori: Zhu, Bing-Mei, McLaughlin, Sara K., Na, Risu, Liu, Jie, Cui, Yongzhi, Martin, Cyril, Kimura, Akiko, Robinson, Gertraud W., Andrews, Nancy C., Hennighausen, Lothar
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2008
Teme:
Red Cells
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518907/
https://ncbi.nlm.nih.gov/pubmed/18552213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-127480
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