Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

Iron is essential for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated. Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythrocyt...

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Détails bibliographiques
Auteurs principaux: Zhu, Bing-Mei, McLaughlin, Sara K., Na, Risu, Liu, Jie, Cui, Yongzhi, Martin, Cyril, Kimura, Akiko, Robinson, Gertraud W., Andrews, Nancy C., Hennighausen, Lothar
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2008
Sujets:
Red Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518907/
https://ncbi.nlm.nih.gov/pubmed/18552213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-127480
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