Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

Iron is essential for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated. Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythrocyt...

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Detalles Bibliográficos
Main Authors: Zhu, Bing-Mei, McLaughlin, Sara K., Na, Risu, Liu, Jie, Cui, Yongzhi, Martin, Cyril, Kimura, Akiko, Robinson, Gertraud W., Andrews, Nancy C., Hennighausen, Lothar
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Red Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518907/
https://ncbi.nlm.nih.gov/pubmed/18552213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-127480
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