Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl

The NUP98-HOXD13 (NHD13) fusion gene occurs in patients with myelodysplastic syndrome (MDS) and acute nonlymphocytic leukemia (ANLL). We reported that transgenic mice expressing NHD13 develop MDS, and that more than half of these mice eventually progress to acute leukemia. The latency period suggest...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Slape, Christopher, Liu, Leah Y., Beachy, Sarah, Aplan, Peter D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518902/
https://ncbi.nlm.nih.gov/pubmed/18566322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-135186
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky