Leukemic transformation in mice expressing a NUP98-HOXD13 transgene is accompanied by spontaneous mutations in Nras, Kras, and Cbl

The NUP98-HOXD13 (NHD13) fusion gene occurs in patients with myelodysplastic syndrome (MDS) and acute nonlymphocytic leukemia (ANLL). We reported that transgenic mice expressing NHD13 develop MDS, and that more than half of these mice eventually progress to acute leukemia. The latency period suggest...

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Main Authors: Slape, Christopher, Liu, Leah Y., Beachy, Sarah, Aplan, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518902/
https://ncbi.nlm.nih.gov/pubmed/18566322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-135186
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