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Preventing Voltage-dependent Gating of Anthrax Toxin Channels Using Engineered Disulfides
The channel-forming component of anthrax toxin, (PA(63))(7), is a heptameric water-soluble protein at neutral pH, but under acidic conditions it spontaneously inserts into lipid bilayers to form a 14-stranded β-barrel ion-conducting channel. This channel plays a vital role in anthrax pathogenesis be...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518729/ https://ncbi.nlm.nih.gov/pubmed/18725530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200809984 |
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