Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Autophagy is the engulfment of cytosol and organelles by double-membrane vesicles termed autophagosomes. Autophagosome formation is known to require phosphatidylinositol 3-phosphate (PI(3)P) and occurs near the endoplasmic reticulum (ER), but the exact mechanisms are unknown. We show that double FYV...

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Autores principales: Axe, Elizabeth L., Walker, Simon A., Manifava, Maria, Chandra, Priya, Roderick, H. Llewelyn, Habermann, Anja, Griffiths, Gareth, Ktistakis, Nicholas T.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2008
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518708/
https://ncbi.nlm.nih.gov/pubmed/18725538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200803137
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