P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

BACKGROUND: The purinergic receptor P2x7 is expressed on myeloid cells as well as on CNS glial cells, and P2x7 activation has been shown to increase both glial and T-cell activation. These properties suggest a role in the development of autoimmune disease including multiple sclerosis. METHODS: The a...

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Autors principals: Sharp, Anthony J, Polak, Paul E, Simonini, Vittoria, Lin, Shao X, Richardson, Jill C, Bongarzone, Ernesto R, Feinstein, Douglas L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2008
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518548/
https://ncbi.nlm.nih.gov/pubmed/18691411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-33
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