The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells

We recently reported that megalin is subjected to regulated intramembrane proteolysis (RIP) and includes 1) protein kinase C (PKC)-regulated, metalloprotease-mediated ectodomain shedding producing a membrane-bound megalin COOH-terminal fragment (MCTF) and 2) γ-secretase-mediated cleavage of the MCTF...

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Bibliografiske detaljer
Main Authors: Li, Yuanli, Cong, Rong, Biemesderfer, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2008
Fag:
Receptors and Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518424/
https://ncbi.nlm.nih.gov/pubmed/18495814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00037.2008
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