CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer

BACKGROUND: Chemoresistance is the main obstacle to cure in most malignant diseases. Anthracyclines are among the main drugs used for breast cancer therapy and in many other malignant conditions. Single parameter analysis or global gene expression profiles have failed to identify mechanisms causing...

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Detalhes bibliográficos
Main Authors: Chrisanthar, Ranjan, Knappskog, Stian, Løkkevik, Erik, Anker, Gun, Østenstad, Bjørn, Lundgren, Steinar, Berge, Elisabet O., Risberg, Terje, Mjaaland, Ingvil, Mæhle, Lovise, Engebretsen, Lars Fredrik, Lillehaug, Johan Richard, Lønning, Per Eystein
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518116/
https://ncbi.nlm.nih.gov/pubmed/18725978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003062
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