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Hinge stiffness is a barrier to RNA folding
Cation-mediated RNA folding from extended to compact, biologically active conformations relies on a temporal balance of forces. The Mg(2+)-mediated folding of the Tetrahymena thermophila ribozyme is characterized by rapid non-specific collapse followed by tertiary contact induced compaction. This pa...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2518058/ https://ncbi.nlm.nih.gov/pubmed/18471829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.04.013 |
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