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Analysis of Protein Covalent Modification by Xenobiotics using a Covert Oxidatively Activated Tag: Raloxifene Proof-of-Principle Study
Numerous xenobiotics, including therapeutics agents, are substrates for bioactivation to electrophilic reactive intermediates that may covalently modify biomolecules. Selective estrogen receptor modulators (SERMs) are in clinical use for long-term therapy of postmenopausal syndromes and chemoprevent...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2517578/ https://ncbi.nlm.nih.gov/pubmed/16167842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx0501738 |
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