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UTERINE PEROXIDASE CATALYZED FORMATION OF DI-QUINONE METHIDES FROM THE SELECTIVE ESTROGEN RECEPTOR MODULATORS (SERMS) RALOXIFENE AND DESMETHYLATED ARZOXIFENE
Long term usage of the selective estrogen receptor modulator (SERM) tamoxifen has been associated with an increased risk of endometrial cancer. One potential mechanism of tamoxifen induced carcinogenesis involves metabolism to reactive intermediates, such as an o-quinone, quinone methide, and carboc...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2507766/ https://ncbi.nlm.nih.gov/pubmed/17630709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7001367 |
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