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Second coiled-coil domain of KCNQ channel controls current expression and subfamily specific heteromultimerization by salt bridge networks

KCNQ channels carry the slowly activating, voltage-dependent M-current in excitable cells such as neurons. Although the KCNQ2 homomultimer can form a functional voltage-gated K(+) channel, heteromultimerization with KCNQ3 produces a > 10-fold increase in current amplitude. All KCNQ channels conta...

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Detalhes bibliográficos
Main Authors: Nakajo, Koichi, Kubo, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517212/
https://ncbi.nlm.nih.gov/pubmed/18440995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.148601
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