Flexibility of Aromatic Residues in the Active-Site Gorge of Acetylcholinesterase: X-ray versus Molecular Dynamics

The high aromatic content of the deep and narrow active-site gorge of acetylcholinesterase (AChE) is a remarkable feature of this enzyme. Here, we analyze conformational flexibility of the side chains of the 14 conserved aromatic residues in the active-site gorge of Torpedo californica AChE based on...

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Hlavní autoři: Xu, Yechun, Colletier, Jacques-Philippe, Weik, Martin, Jiang, Hualiang, Moult, John, Silman, Israel, Sussman, Joel L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2008
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517048/
https://ncbi.nlm.nih.gov/pubmed/18502801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.129601
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