Oxidative Stress Promotes Ligand-independent and Enhanced Ligand-dependent Tumor Necrosis Factor Receptor Signaling

Tumor necrosis factor (TNF) receptor 1 (TNFR1, p55) and 2 (TNFR2, p75) are characterized by several cysteine-rich modules in the extracellular domain, raising the possibility that redox-induced modifications of these cysteine residues might alter TNFR function. To test this possibility, we examined...

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Autores principales: Ozsoy, Hatice Z., Sivasubramanian, Natarajan, Wieder, Eric D., Pedersen, Steen, Mann, Douglas L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Mechanisms of Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516989/
https://ncbi.nlm.nih.gov/pubmed/18544535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802967200
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