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The α(1S) III-IV Loop Influences 1,4-Dihydropyridine Receptor Gating but Is Not Directly Involved in Excitation-Contraction Coupling Interactions with the Type 1 Ryanodine Receptor
In skeletal muscle, coupling between the 1,4-dihydropyridine receptor (DHPR) and the type 1 ryanodine receptor (RyR1) underlies excitation-contraction (EC) coupling. The III-IV loop of the DHPR α(1S) subunit binds to a segment of RyR1 in vitro, and mutations in the III-IV loop alter the voltage depe...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516988/ https://ncbi.nlm.nih.gov/pubmed/18556650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804312200 |
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