The α(1S) III-IV Loop Influences 1,4-Dihydropyridine Receptor Gating but Is Not Directly Involved in Excitation-Contraction Coupling Interactions with the Type 1 Ryanodine Receptor

In skeletal muscle, coupling between the 1,4-dihydropyridine receptor (DHPR) and the type 1 ryanodine receptor (RyR1) underlies excitation-contraction (EC) coupling. The III-IV loop of the DHPR α(1S) subunit binds to a segment of RyR1 in vitro, and mutations in the III-IV loop alter the voltage depe...

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Autores principales: Bannister, Roger A., Grabner, Manfred, Beam, Kurt G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Membrane Transport, Structure, Function, and Biogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516988/
https://ncbi.nlm.nih.gov/pubmed/18556650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804312200
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