Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that determine this potential have remained largely elusive. Here, we find that insulin and insulin-like growth factor receptors (IR and IGF-1R) deter...

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Autori principali: Stachelscheid, Heike, Ibrahim, Hady, Koch, Linda, Schmitz, Annika, Tscharntke, Michael, Wunderlich, F Thomas, Scott, Jeanie, Michels, Christian, Wickenhauser, Claudia, Haase, Ingo, Brüning, Jens C, Niessen, Carien M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516889/
https://ncbi.nlm.nih.gov/pubmed/18650937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.141
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