A new nonhydrolyzable reactive cGMP analogue, (Rp)-Guanosine-3′, 5′-cyclic-S-(4-bromo-2, 3-dioxobutyl)monophosphorothioate, which targets the cGMP binding site of human platelet PDE3A

The amino acids involved in substrate (cAMP) binding to human platelet cGMP-inhibited cAMP phosphodiesterase (PDE3A) are identified. Less is known about the inhibitor (cGMP) binding site. We have now synthesized a nonhydrolyzable reactive cGMP analog, Rp-guanosine-3′, 5′-cyclic-S-(4-bromo-2, 3-dioxo...

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Detalhes bibliográficos
Main Authors: Hung, Su H., Liu, Andy H., Pixley, Robin A., Francis, Penelope, Williams, LaTeeka D., Matsko, Christopher M., Barnes, Karine D., Sivendran, Sharmila, Colman, Roberta F., Colman, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516375/
https://ncbi.nlm.nih.gov/pubmed/18394675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2008.02.006
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