Excessive genomic DNA copy number variation in the Li–Fraumeni cancer predisposition syndrome

DNA copy number variations (CNVs) are a significant and ubiquitous source of inherited human genetic variation. However, the importance of CNVs to cancer susceptibility and tumor progression has not yet been explored. Li–Fraumeni syndrome (LFS) is an autosomal dominantly inherited disorder character...

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Библиографические подробности
Главные авторы: Shlien, Adam, Tabori, Uri, Marshall, Christian R., Pienkowska, Malgorzata, Feuk, Lars, Novokmet, Ana, Nanda, Sonia, Druker, Harriet, Scherer, Stephen W., Malkin, David
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2008
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516272/
https://ncbi.nlm.nih.gov/pubmed/18685109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802970105
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