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Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis
The enzymatic activities of three proteins encoded by the thienamycin gene cluster of Streptomyces cattleya (ThnR, ThnH, and ThnT) have been shown to incrementally cleave CoA to afford the active side-chain component of the β-lactam antibiotic thienamycin. These results supersede proposals based on...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516261/ https://ncbi.nlm.nih.gov/pubmed/18678912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804500105 |
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