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Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation
Mice deficient in cholesterol 24-hydroxylase exhibit reduced rates of cholesterol synthesis and other non-sterol isoprenoids that arise from the mevalonate pathway. These metabolic abnormalities, in turn, impair learning in the whole animal and hippocampal long-term potentiation (LTP) in vitro. Here...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2516227/ https://ncbi.nlm.nih.gov/pubmed/18685105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805556105 |
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