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Brain cholesterol turnover required for geranylgeraniol production and learning in mice

The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as geranylgeraniol. In the brain, a fraction of cholesterol is metabolized in neurons by the enzyme cholesterol 24-hydroxylase, and this depletion activates the mevalonate pathway. Brains from mice lacking 24-hydroxylase exc...

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Detalhes bibliográficos
Main Authors: Kotti, Tiina J., Ramirez, Denise M. O., Pfeiffer, Brad E., Huber, Kimberly M., Russell, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1450160/
https://ncbi.nlm.nih.gov/pubmed/16505352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600316103
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