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Brain cholesterol turnover required for geranylgeraniol production and learning in mice
The mevalonate pathway produces cholesterol and nonsterol isoprenoids, such as geranylgeraniol. In the brain, a fraction of cholesterol is metabolized in neurons by the enzyme cholesterol 24-hydroxylase, and this depletion activates the mevalonate pathway. Brains from mice lacking 24-hydroxylase exc...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1450160/ https://ncbi.nlm.nih.gov/pubmed/16505352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0600316103 |
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