AIMP2/p38, the scaffold for the multi-tRNA synthetase complex, responds to genotoxic stresses via p53

AIMP2/p38 is a scaffolding protein required for the assembly of the macromolecular tRNA synthetase complex. Here, we describe a previously unknown function for AIMP2 as a positive regulator of p53 in response to genotoxic stresses. Depletion of AIMP2 increased resistance to DNA damage-induced apopto...

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Detalhes bibliográficos
Main Authors: Han, Jung Min, Park, Bum-Joon, Park, Sang Gyu, Oh, Young Sun, Choi, So Jung, Lee, Sang Won, Hwang, Soon-Kyung, Chang, Seung-Hee, Cho, Myung-Haing, Kim, Sunghoon
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516205/
https://ncbi.nlm.nih.gov/pubmed/18695251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800297105
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