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Aminoacyl tRNA synthetases and their connections to disease

Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions are catalyzed by an ancient group of 20 enzymes (one for each amino acid) known as aminoacyl tRNA synthetases (AARSs). Surprisingly, the etiology of specific diseases—including cancer, neuronal pathologies, auto...

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Autori principali: Park, Sang Gyu, Schimmel, Paul, Kim, Sunghoon
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516211/
https://ncbi.nlm.nih.gov/pubmed/18682559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802862105
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