Mutagenic and Recombinagenic Responses to Defective DNA Polymerase δ Are Facilitated by the Rev1 Protein in pol3-t Mutants of Saccharomyces cerevisiae

Defective DNA replication can result in substantial increases in the level of genome instability. In the yeast Saccharomyces cerevisiae, the pol3-t allele confers a defect in the catalytic subunit of replicative DNA polymerase δ that results in increased rates of mutagenesis, recombination, and chro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mito, Erica, Mokhnatkin, Janet V., Steele, Molly C., Buettner, Victoria L., Sommer, Steve S., Manthey, Glenn M., Bailis, Adam M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Genetics Society of America 2008
Pynciau:
Investigations
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516059/
https://ncbi.nlm.nih.gov/pubmed/18711219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.108.089821
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