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Double-strand breaks associated with repetitive DNA can reshape the genome

Ionizing radiation is an established source of chromosome aberrations (CAs). Although double-strand breaks (DSBs) are implicated in radiation-induced and other CAs, the underlying mechanisms are poorly understood. Here, we show that, although the vast majority of randomly induced DSBs in G(2) diploi...

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Autors principals: Argueso, Juan Lucas, Westmoreland, James, Mieczkowski, Piotr A., Gawel, Malgorzata, Petes, Thomas D., Resnick, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515620/
https://ncbi.nlm.nih.gov/pubmed/18701715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804529105
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