Tetrameric Ctp1 coordinates DNA binding and bridging in DNA double strand break repair

Ctp1 (aka CtIP or Sae2) collaborates with Mre11–Rad50–Nbs1 to initiate repair of DNA double strand breaks (DSBs), but its function(s) remain enigmatic. We report that tetrameric Schizosaccharomyces pombe Ctp1 harbors multivalent DNA-binding and bridging activities. Through structural and biophysical...

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Publicat a:Nat Struct Mol Biol
Autors principals: Andres, Sara N., Appel, C. Denise, Westmoreland, Jim, Williams, Jessica S., Nguyen, Yvonne, Robertson, Patrick D., Resnick, Michael A., Williams, R. Scott
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4318798/
https://ncbi.nlm.nih.gov/pubmed/25580577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2945
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