Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcγRI, FcγRIII, and FcγRIV

Despite the demonstrated clinical efficacy of CD20 monoclonal antibody (mAb) for lymphoma therapy, the in vivo mechanisms of tumor depletion remain controversial and variable. To identify the molecular mechanisms responsible for lymphoma killing by CD20 mAb in a homologous system amenable to mechani...

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Autores principales: Minard-Colin, Veronique, Xiu, Yan, Poe, Jonathan C., Horikawa, Mayuka, Magro, Cynthia M., Hamaguchi, Yasuhito, Haas, Karen M., Tedder, Thomas F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2008
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515149/
https://ncbi.nlm.nih.gov/pubmed/18495955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-135160
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