Immune complexes formed following the binding of anti–platelet factor 4 (CXCL4) antibodies to CXCL4 stimulate human neutrophil activation and cell adhesion

We tested the possibility that immune complexes formed following platelet factor 4 (PF4/CXCL4) binding to anti-PF4 antibody can stimulate neutrophil activation, similar to previous reports with platelets. Monoclonal Abs against PF4 and IgG from a heparin-induced thrombocytopenia (HIT) patient were a...

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Detalhes bibliográficos
Main Authors: Xiao, Zhihua, Visentin, Gian P., Dayananda, Kannayakanahalli M., Neelamegham, Sriram
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515144/
https://ncbi.nlm.nih.gov/pubmed/18539895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-04-153288
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