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Dexamethasone-induced apoptotic mechanisms in myeloma cells investigated by analysis of mutant glucocorticoid receptors

The mechanism by which the glucocorticoid (GC) dexamethasone induces apoptosis in multiple myeloma (MM) cells is unknown, although previous work suggests that either transactivation through the glucocorticoid response element (GRE), transrepression of NF-κB, phosphorylation of RAFTK (Pyk2), or induc...

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Autori principali: Sharma, Sanjai, Lichtenstein, Alan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2515111/
https://ncbi.nlm.nih.gov/pubmed/18515658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-11-124156
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