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Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis

We have generated null mutant mice that lack expression of all isoforms encoded by the trkC locus. These mice display a behavioral phenotype characterized by a loss of proprioceptive neurons. Neuronal counts of sensory ganglia in the trkC mutant mice reveal less severe losses than those in NT-3 null...

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Détails bibliographiques
Auteurs principaux: Tessarollo, Lino, Tsoulfas, Pantelis, Donovan, Michael J., Palko, Mary Ellen, Blair-Flynn, Janet, Hempstead, Barbara L., Parada, Luis F.
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences of the USA 1997
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC25113/
https://ncbi.nlm.nih.gov/pubmed/9405689
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