Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis

We have generated null mutant mice that lack expression of all isoforms encoded by the trkC locus. These mice display a behavioral phenotype characterized by a loss of proprioceptive neurons. Neuronal counts of sensory ganglia in the trkC mutant mice reveal less severe losses than those in NT-3 null...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tessarollo, Lino, Tsoulfas, Pantelis, Donovan, Michael J., Palko, Mary Ellen, Blair-Flynn, Janet, Hempstead, Barbara L., Parada, Luis F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25113/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9405689/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.26.14776
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